在肿瘤免疫学和免疫治疗领域的最新进展，已产生的免疫检查点蛋白的识别，可以被人抗体阻断。免疫检查点通路包含共刺激蛋白和抑制蛋白。共刺激受体转换信号促进对抗病原体的免疫功能。另一方面，抑制性受体，负调节T细胞的激活，以防止过度的炎症反应。直接针对细胞毒性T淋巴细胞抗原-4（CTLA-4）和程序性死亡-1（PD-1）的免疫调节抗体，在黑色素瘤和其他类型的肿瘤治疗中表现出巨大的希望。
这些药剂通常被称为“检查点抑制剂”，因为它们阻断正常的T细胞免疫的负调节因子。很多其他的免疫检查点途径，可能是新疗法的目标，已经确定且目前正在开发用于临床试验。Biovision提供全面的免疫检查点蛋白和抗体，支持免疫检查点阻断研究。这些产品在多种检测实验都表现出一致性和极佳的性能。
检查点阻断抗体（Checkpoint Blocking Antibodies）
| Product Name | Catalog No. | Size | Host | Species | Application |
| 4-1BBL Antibody | 93-5369-30T, 100 | 30 μg, 100 μg | Rb | hu | WB, IHC |
| BTLA Polyclonal Antibody | 93-A1082-50 | 50 μg | Rb | hu | WB, IHC, IF |
| CD137 Polyclonal Antibody | 93-A1088-100 | 100 μl | Rb | hu | WB, ELISA, IF |
| CD137/4-1BB Antibody | 93-A1087-50 | 50 μl | Rb | hu, ms, rt | IHC |
| CD223 (LAG3) Polyclonal Antibody | 93-A1067-100 | 100 μg | Rb | hu, ms | WB, IHC, FC |
| CD27 Polyclonal Antibody | 93-A1074-100 | 100 μg | Rb | hu | WB, FC |
| CD28 Polyclonal Antibody | 93-A1076-100 | 100 μg | Rb | hu | WB, ELISA |
| CTLA4 Polyclonal Antibody | 93-A1083-100 | 100 μl | Rb | hu | WB, IHC |
| GITR / TNFSF18 Monoclonal Antibody | 93-A1086-50 | 50 μg | Ms | hu | WB |
| GITR / TNFSF18 Polyclonal Antibody | 93-A1085-100 | 100 μl | Rb | hu | WB |
| HVEM / TNFRSF14 Antibody | 93-A1084-50 | 50 μg | Rb | hu, ms | WB, IHC, IF |
| OX40 Antibody | 93-3890-100 | 100 μg | Rb | Rt | WB |
| PD-1/PDCD1 Antibody | 93-6931-50 | 50 μg | Rb | hu | WB, ELISA |
| Tim-3 Antibody | 93-3808-100 | 100 μg | Rb | hu | WB, IHC |
免疫检查点蛋白（Immune Checkpoint Proteins）
| Product Name | Catalog No. | Size | Source |
| 4-1BB Receptor, human recombinant | 93-4370-100, -1000 | 100 μg, 1000 μg | E. coli |
| CD226, human recombinant | 93-7310-100 | 100 μg | E. coli |
| CD40Ligand/TRAP, human recombinant | 93-4014-10, -1000 | 10 μg, 1000 μg | E. coli |
| Human CellExp™ 4-1BB Ligand/TNFSF9, Human recombinant | 93-9240-10, -25 | 10 μg, 25 μg | HEK293 cells |
| Human CellExp™ B7-2 /CD86, human recombinant | 93-7496-10, -50 | 10 μg, 50 μg | HEK293 cells |
| Human CellExp™ B7-H3 / CD276, Human recombinant | 93-9239-10, -50 | 10 μg, 50 μg | HEK293 cells |
| Human CellExp™ B7-H5 / VISTA, Human recombinant | 93-9242-10, -50 | 10 μg, 50 μg | HEK293 cells |
| Human CellExp™ BTLA, Human recombinant | 93-9228-10, -50 | 10 μg, 50 μg | HEK293 cells |
| Human CellExp™ CD155, human recombinant | 93-7462-10, -50 | 10 μg, 50 μg | HEK293 cells |
| Human CellExp™ CD160/BY55, human recombinant | 93-7386-10, -50 | 10 μg, 50 μg | HEK293 cells |
| Human CellExp™ CD172A / SIRP, human recombinant | 93-7506-50 | 10 μg, 50 μg | HEK293 cells |
| Human CellExp™ CD244 / 2B4 / SLAMF4, Human recombinant | 93-7374-10, -50 | 10 μg, 50 μg | HEK293 cells |
| Human CellExp™ CD27 / TNFRSF7, Human recombinant | 93-9243-100, -25 | 10 μg, 25 μg | HEK293 cells |
| Human CellExp™ CD273 / B7-DC / PD-L2, Human recombinant | 93-7369-10, -50 | 10 μg, 50 μg | HEK293 cells |
| Human CellExp™ CD28, Human recombinant | 93-9237-10, -50 | 10 μg, 50 μg | HEK293 cells |
| Human CellExp™ CD47, Human recombinant | 93-7385-10 | 10 μg | HEK293 cells |
| Human CellExp™ CD80, Human recombinant | 93-7383-10, 50 | 10 μg, 50 μg | HEK293 cells |
| Human CellExp™ CTLA4/CD152, human recombinant | 93-7476-20, -100 | 10 μg, 100 μg | HEK293 cells |
| Human CellExp™ GITR / TNFRSF18, Human recombinant | 93-9231-10, -50 | 10 μg, 50 μg | HEK293 cells |
| Human CellExp™ Human CD40/ TNFRSF5, Human recombinant | 93-9230-10, -50 | 10 μg, 50 μg | HEK293 cells |
| Human CellExp™ HVEM/TNFRSF14, Human recombinant | 93-7466-20, -100 | 20 μg, 100 μg | HEK293 cells |
| Human CellExp™ ICOS / CD278, Human recombinant | 93-9238-10, -100 | 10 μg, 100 μg | HEK293 cells |
| Human CellExp™ ICOSLG /B7-H2 /CD275, Human recombinant | 93-7426-20, -100 | 20 μg, 100 μg | HEK293 cells |
| Human CellExp™ OX40 Ligand / TNFSF4, Human recombinant | 93-9244-10, -50 | 10 μg, 50 μg | HEK293 cells |
| Human CellExp™ PD-1 /PDCD1, C-Fc Tag, Human recombinant | 93-7500-10, -50 | 10 μg, 50 μg | HEK293 cells |
| Human CellExp™ PD-1 /PDCD1, C-Fc Tag, Mouse recombinant | 93-7503-10, -50 | 10 μg, 50 μg | HEK293 cells |
| Human CellExp™ PD-1 /PDCD1, Human recombinant | 93-7498-10, -50 | 10 μg, 50 μg | HEK293 cells |
| Human CellExp™ PD-1 /PDCD1, Mouse recombinant | 93-7499-10, -50 | 10 μg, 50 μg | HEK293 cells |
| Human CellExp™ PD-L1 /CD274 /B7-H1, Human recombinant | 93-7429-10, -50 | 10 μg, 50 μg | HEK293 cells |
| Human CellExp™ PD-L1 /CD274 /B7-H1, Mouse recombinant | 93-7428-10, -50 | 10 μg, 50 μg | HEK293 cells |
| Human CellExp™ TIGIT, human recombinant | 93-8015-10 | 10 μg | HEK293 cells |
| Human CellExp™ TIM3/HAVR2 Protein, Human Recombinant | 93-P1002-20, -100 | 20 μg, 100 μg | HEK293 cells |
| Human CellExp™ TIM3/HAVR2 Protein, Human Recombinant | 93-P1002-20, -100 | 20 μg, 100 μg | HEK293 cells |
| Human CellExp™ TNFRSF4/OX40 /CD134, human recombinant | 93-7438-10 | 10 μg | HEK293 cells |
| Human CellExp™ VTCN1, Human recombinant | 93-7412-10, -50 | 10 μg, 50 μg | HEK293 cells |
| Human CellExp™LAG3 /CD223, Human recombinant | 93-7278-10, -50 | 10 μg, 50 μg | HEK293 cells |
| PD-1/PDCD1, Human Recombinant | 93-P1024-10, -50 | 10 μg, 50 μg | E. coli |
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