BP1 Antibody (NB100-304)

Application: IHC

Sample Tested: Mouse thymocytes

Species: Mouse

Results: I needed to localize DSB repair at a single locus, so IHC was combined with DNA FISH. Many other antibodies
failed because DNA FISH requires heating the cells to 80 degrees C which denatures most proteins. This anti-53BP1
antibody resulted in discrete, bright foci
regardless of FISH hybridization.

FANCD2 Antibody (NB100-182)

Application: Western blot Sample Tested: PD20 cell line Species: Human

Ogg1 Antibody (NB100-106)

Application: IHC

Sample Tested: Human foreskin, adult ski, engineered human skin, keratinocytes, HaCaT cells

Species: Human

产品引用文献：

[53BP1 Antibody NB100-904] Coleman KA, Greenberg RA. The BRCA1-RAP80 complex regulates
DNA repair mechanism utilization by restricting end resection. J Biol Chem. 2011 Feb 18. [PMID 21335604]

[53BP1 Antibody NB100-904] Zhang Y-W, Regairaz M, Seiler JA, et al. Poly(ADP-ribose) polymerase and XPF-ERCC1
participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells.
Nucleic Acids Res. 2011.[PMID 21227924]

[53BP1 Antibody NB100-304] Zhang M, Atkinson RL, Rosen JM. Selective targeting of radiation-resistant tumor-initiating
cells. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3522-7. [PMID: 20133717]

[Blooms Syndrome Protein Blm Antibody (NBP1-46851] Rao VA, Fan AM, Meng L, Doe CF, North PS, Hickson ID,
Pommier Y. Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX
after topoisomerase I-induced replication damage. Mol Cell Biol. 2005 Oct;25(20):8925-37.

[Blooms Syndrome Protein Blm Antibody NBP1-46851] Shimura T, Torres MJ, Martin MM, Rao VA,
Pommier Y, Katsura M, Miyagawa K, Aladjem MI. Bloom’s syndrome helicase and Mus81 are required to induce transient
double-strand DNA breaks in response to DNA replication stress. J Mol Biol. 2008 Jan 25;375(4):1152-64.

[FANCD2 Antibody NB100-182] Lyakhovich A, Surrallés J. Constitutive activation of caspase-3 and Poly ADP
ribose polymerase cleavage in fanconi anemia cells. Mol Cancer Res. 2010 Jan;8(1):46-56. [PMID: 20068062]

[Ogg1 Antibody NB100-106] Karihtala P, Kauppila S, Puistola U, Jukkola-Vuorinen A. Absence of the DNA
repair enzyme human 8-oxoguanine glycosylase

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