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Biovision与表观遗传学

作者:杭州联科生物技术股份有限公司 2015-01-27T22:01 (访问量:2817)


表观遗传学

    研究DNA序列不变而发生的基因表达可遗传变化的一门遗传学分支学科
    DNA的化学修饰,可折叠和复杂的构象导致基因打开或关闭
    最好的研究表观遗传学机制是CpG DNA甲基化(DNA methylation)和组蛋白修饰(histone modifications)

与表观遗传学相关的疾病

癌症Cancer
心血管疾病Cardiovascular Disease
糖尿病/胰岛素抗性Diabetes/Insulin Resistance
神经系统疾病如阿尔茨海默氏症、精神分裂症Neurological Disorders such as Alzheimer’s, Schizophrenia
自身免疫性疾病,如系统性红斑狼疮和类风湿性关节炎Autoimmune Disorders such as Systemic Lupus Erythematosus and Rheumatoid Arthritis

与组蛋白Histones研究相关产品:

1)抗体
Acetyl-histone H2A Antibody (# 3653)
Acetyl-histone H2B Antibody (# 3654)
Acetyl-histone H4 Antibody (# 3656)
Histone H2A Antibody (#3621)
Histone H2B Antibody (# 3622)
Histone 2AX Antibody (# 3761)
Histone H3 Antibody (# 3623)
Histone H4 Antibody (# 3624)

(2)多肽
Histone H2A Blocking Peptide (# 3621BP)
Histone H2B Blocking Peptide (# 3622BP)
Histone H3 Blocking Peptide (# 3623BP)
Histone H4 Blocking Peptide (#3624BP)
Histone H3 Peptide-Biotin Conjugate (#2233)

组蛋白乙酰转移酶Histone Acetyl Transferases(HAT)相关产品


1.抗体: HAT1 (# 3689), HAT2 (# 3692) 和HAT3 (# 3707)
2.HAT1的阻断肽Blocking Peptides against HAT1 (# 3689BP), HAT2 (# 3692BP) and HAT3 (# 3707BP)
3.HAT比色检测试剂盒HAT Assay Kit- K332
4.HAT活化剂HAT Activators-CTPB (# 2086)
5.HAT抑制剂HAT Inhibitors-Curcumin (# 1850), Garcinol (# 2088), Anacardic Acid (# 1849), p300-CBP inhibitor (# 1948)
6.重组蛋白Recombinant Proteins-HAT/PCAF (#1137)

组蛋白脱乙酰基酶Histone Deacetylases(HDAC’s & SIRT’s)相关产品


1.抗体:HDAC1 (# 3601),HDAC2 (# 3602),HDAC3 (# 3603),HDAC4 (# 3604, 3604A),HDAC5 (# 3605),HDAC6 (# 3606),HDAC7 (# 3607),HDAC8 (# 3608),HDAC9 (# 3609),HDAC10 (# 3610),HDAC11 (# 3611P),SIRT3 (# 3223),SIRT4 (# 3224),SIRT5 (# 3225),SIRT7 (# 3099)
HDAC家族抗体套装HDAC Family Antibody Set (# K333-11-30)—DAC1-11
2.阻断肽Blocking Peptides:HDAC1 (# 3601BP),HDAC2 (# 3602BP),HDAC3 (# 3603BP),HDAC4 (# 3604BP),HDAC5 (# 3605BP),HDAC6 (# 3606BP),HDAC7 (# 3607BP),HDAC8 (# 3608BP),HDAC9 (# 3609BP),HDAC10 (# 3610BP),HDAC11 (# 3611BP),SIRT3 (# 3223BP),SIRT4 (3224BP),SIRT5 (3225BP),SIRT7 (3099BP)
3.HDAC检测试剂盒
HDAC’s, HDAC3 and HDAC8 Activity Assay (K330,K331, K343, K348)
In Situ HDAC Activity Assay (K339)
HDAC Immunoprecipitation-Activity Assay (K341, K342, K344)
HDAC, HDAC3 & HDAC8 Inhibitor Screening Assay (K340, K363, K368)
Sirtuin Activity Assay and Inhibitor Screening Kit (K322)
4.HDAC抑制剂(HDAC Inhibitors)
DiscoveryPak™ HDAC Inhibitor Set (K851-6)
DiscoveryPak™ HDAC Inhibitor Set II (K876-7)
5.重组蛋白Recombinant Proteins:HDAC3 (#7613),HDAC8 (#7618),Sirtuin2 (# 7632)

组蛋白和DNA甲基转移酶Histone and DNAMethyltransferases(HMT and DMT)相关产品

  • 抗体:CARM1 (# 3734R),DNMT1 (# 3946),SUV38H1 (# 3942),LSD1 (# 3129),PRMT1 (#3792),PRMT5 (# 3935),PRMT6 (#3086),PRMT7 (#3059)
  • 阻断肽Blocking Peptides:CARM1 (# 3734RBP),DNMT1 (# 3946BP),LSD1 (# 3129BP),PRMT5 (# 3935BP),PRMT6 (# 3086BP),PRMT7 (# 3059BP)
  • 阻断剂:3 Deazaneplanocin (# 2060),5-aza-2’-deoxycytidine (# 1754),5-azacytidine (# 1854),AMI-1 (# 1943),BIX01294 (# 1678),Lomeguatrib (# 2224),RG108 (# 1679),UNC0638 (# 1933)
  • 辅助因子:S-adenosyl-L-methionine disulfatetosylate (# 2077)
  • 重组蛋白:Human PRMT1 (# 4865),Mouse PRMT1 (# 4868)

组蛋白脱甲基酶Histone Demethylases(HDM)相关产品

  • 抑制剂Inhibitors: GSK-J1 (# 2260), GSK-J4 hydrochloride (# 2259), β-lapachone (# 2262), IOX1 (2266)
  • JMJD1A Antibody (# 3273)
  • JMJD1A Blocking Peptide (# 3273BP)

与Bromodomain有关产品:

Bromodomain:~ 110 氨基酸
Readers of ε-N-acetyl lysine (Kac) marks
在染色质组装和重构中作为转录因子或调节因子或作为甲基转移酶起作用


    • 抗体Bromodomain Antibodies: BRD8 (# 3738, # 3506)
    • 阻断肽Blocking peptide:BRD8 (# 3506BP)
    • 蛋白:BRD1 (# 7645),BRD2-BD1 (#7646),BRD2-BD1&2 (# 7647),BRD2-BD2 (# 7648),BRD4-BD1 (# 7643),BRD4-BD2 (# 7644),BRD9 (# 7649),Brdt-BD1 (# 7641),BRG1 (# 7650)
    • 抑制剂:JQ1 (# 2070),I-BET151 (# 2220),PFI-1 (# 2203)



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