FITC标记的磷酸化gp130抗体
产品名称： FITC标记的磷酸化gp130抗体
英文名称： Anti-phospho-CD130/gp130 (Ser782)/FITC
产品编号： HZ-10122R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-phospho-CD130/gp130 (Ser782)/FITC Conjugated antibody
FITC标记的磷酸化gp130抗体
| 英文名称 | Anti-phospho-CD130/gp130 (Ser782)/FITC |
| 中文名称 | FITC标记的磷酸化gp130抗体 |
| 别 名 | gp130 (phospho S782); gp130 (phospho Ser782); p-gp130 (Ser782); Interleukin-6 receptor subunit beta; IL-6R-beta; Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; CDw130; Oncostatin-M receptor subunit alpha; CD_antigen; CD130; GP130 RAPS; gp130 transducer chain; GP130-RAPS; IL6 ST; IL6R-beta; IL6ST.IL6R-beta; IL6RB_HUMAN; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6RB. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 细胞生物 信号转导 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from human gp130 around the phosphorylation site of Ser782 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: CD130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. Function: Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events. Subunit: Interacts with INPP5D/SHIP1. Forms heterodimers composed of LIPR and IL6ST (type I OSM receptor). Also forms heterodimers composed of OSMR and IL6ST (type II OSM receptor). Homodimer. The homodimer binds two molecules of herpes virus IL6. Component of a hexamer of two molecules each of IL6, IL6R and IL6ST. Interacts with HCK. Subcellular Location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Tissue Specificity: Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells. Post-translational modifications: Phosphorylation of Ser-782 down-regulates cell surface expression. Heavily N-glycosylated. Similarity: Belongs to the type I cytokine receptor family. Type 2 subfamily. Contains 5 fibronectin type-III domains. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Database links: Entrez Gene: 3572 Human Entrez Gene: 16195 Mouse Entrez Gene: 25205 Rat Omim: 600694 Human SwissProt: P40189 Human SwissProt: Q00560 Mouse SwissProt: P40190 Rat Unigene: 532082 Human Unigene: 706627 Human Unigene: 4364 Mouse Unigene: 12138 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
CD130是许多细胞因子共享的信号转导因子，包括白细胞介素6（IL6）、睫状神经营养因子（CNTF）、白血病抑制因子（LIF）和抑瘤素M（OSM）。该蛋白作为细胞因子受体复合物的一部分发挥作用。这种蛋白的激活依赖于细胞因子与它们的受体的结合。vIL6是一种与IL6相关的蛋白，由卡波西肉瘤相关疱疹病毒编码，可以绕过白细胞介素6受体（IL6R）并直接激活该蛋白。敲除小鼠的研究表明编码该蛋白的基因在调节心肌细胞凋亡中起关键作用。另外，已经描述了编码不同亚型的剪接转录变体。