JPH4 Antibody-抗体-抗体-生物在线
深圳市豪地华拓生物科技有限公司
JPH4 Antibody

JPH4 Antibody

商家询价

产品名称: JPH4 Antibody

英文名称: JPH4 Antibody

产品编号: 253983

产品价格: null

产品产地: 美国

品牌商标: Abbiotec

更新时间: null

使用范围: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:00-1:500

深圳市豪地华拓生物科技有限公司
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  • 地址 : 深圳市南山创业路中兴城5栋518
  • 邮编 : 518054
  • 所在区域 : 广东
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  • 邮箱 : order@otwobiotech.com

Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels.  Junctophilins (JPs) are important components of the junctional complexes.  JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM.  Four JPs have been identified as tissue-specific subtypes derived from different genes: JPH1 is expressed in skeletal muscle, JPH2 is detected throughout all muscle cell types, and JPH3 and JPH4 are predominantly expressed in the brain.  In the CNS, both JPH3 and JPH4 are expressed throughout neural sites and contribute to the subsurface cistern formation in neurons. Mice lacking both JPH3 and JPH4 subtypes exhibit serious symptoms such as impaired learning and memory and are accompanied by abnormal nervous functions.