MC4R Antibody-抗体-抗体-生物在线
深圳市豪地华拓生物科技有限公司
MC4R Antibody

MC4R Antibody

商家询价

产品名称: MC4R Antibody

英文名称: MC4R Antibody

产品编号: 254082

产品价格: null

产品产地: 美国

品牌商标: Abbiotec

更新时间: null

使用范围: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:00-1:500

深圳市豪地华拓生物科技有限公司
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  • 地址 : 深圳市南山创业路中兴城5栋518
  • 邮编 : 518054
  • 所在区域 : 广东
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  • 邮箱 : order@otwobiotech.com

The melanocortin-4 receptor (MC4R) is a member of the superfamily of seven transmembrane G-protein coupled receptors that are involved in multiple signal transduction pathways including the cAMP and MAPK signaling pathways.  It is thought that the melanocortin system modulates energy expenditure and insulin sensitivity; activation of the MC4R results in the inhibition of c-Jun N-terminal kinase (JNK) activity and promotes insulin signaling.  MC4R-null mice display maturity onset obesity characterized by hyperphagia, increased adiposity, hyperinsulinaemia and hyperleptinaemia, suggesting that like other obesity-linked genes such as FTO, PTER, and NPC1, MC4R is a potential candidate target for the treatment of obesity.