FITC标记的FBXO36 F-box蛋白相关蛋白36抗体
产品名称： FITC标记的FBXO36 F-box蛋白相关蛋白36抗体
英文名称： Anti-FBXO36/FITC
产品编号： HZ-8470R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-FBXO36/FITC Conjugated antibody
FITC标记的FBXO36 F-box蛋白相关蛋白36抗体
| 产品编号 | bs-8470R-FITC |
| 英文名称 | Anti-FBXO36/FITC |
| 中文名称 | FITC标记的FBXO36 F-box蛋白相关蛋白36抗体 |
| 别 名 | F box only protein 36; F box protein 36; F-box only protein 36; Fbx 36; Fbx36; FBX36_HUMAN; FBXO 36; Fbxo36; FLJ37592; FLJ41090. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 泛素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 22kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FBXO6 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: FBXO36 is a 188 amino acid protein that contains one forty amino acid F-box region, making it a member of the F-box family. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. F-box proteins are members of a large family that regulates cell cycle, immune response, signaling cascades and developmental programs by targeting proteins, such as cyclins, cyclin-dependent kinase inhibitors, IkB-å and ∫-catenin, for degradation by the proteasome after ubiquitination. Functioning as a component of the SCF complex, FBXO36 is thought to recognize and bind to select phosphorylated proteins, thereby promoting their ubiquitination and subsequent degradation. Function: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex Subunit: Directly interacts with SKP1 and CUL1 Similarity: Contains 1 F-box domain. Database links: Entrez Gene: 26270 Human Omim: 605647 Human SwissProt: Q9NRD1 Human Unigene: 464419 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
FBXO36是一个含有140个氨基酸的F盒区的188氨基酸蛋白，使其成为F盒家族的成员。F-盒蛋白是SCF（SKP1-Cul-1-F盒蛋白）型E3泛素连接酶复合体的重要组成部分，参与了泛素化的底物识别和募集。F-盒蛋白是一个大家族的成员，它通过靶向蛋白，如细胞周期素、细胞周期蛋白依赖性激酶抑制剂、IKB-γ和β-连环蛋白，调节泛素化后的蛋白酶体降解，从而调节细胞周期、免疫应答、信号级联和发育程序。FBXO36作为SCF复合物的一个组成部分，被认为是识别和结合选择磷酸化蛋白，从而促进其泛素化和随后的降解。