FITC标记的G蛋白偶联受体147抗体
产品名称： FITC标记的G蛋白偶联受体147抗体
英文名称： Anti-NPFF1 Receptor/FITC
产品编号： HZ-12018R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-NPFF1 Receptor/FITC Conjugated antibody
FITC标记的G蛋白偶联受体147抗体
| 英文名称 | Anti-NPFF1 Receptor/FITC |
| 中文名称 | FITC标记的G蛋白偶联受体147抗体 |
| 别 名 | NPFF1 Receptor; G Protein Coupled Receptor 147; G-protein coupled receptor 147; GPR147; Neuropeptide FF receptor 1; NPFF1; NPFF1_HUMAN; NPFF1R1; NPFFR1; RFamide related peptide receptor OT7T022; RFamide-related peptide receptor OT7T022. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 细胞膜受体 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 48kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GPR147/NPFF1 Receptor (181-225aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Neuropeptide FF 1 Receptor (NPFF1 or hFF1) and Neuropeptide FF 2 Receptor (NPFF2) belong to the G protein-coupled receptor 1 family. Both NPFF1 and NPFF2 are integral membrane proteins that act as receptors for NPAF (A-18- F-amide) and NPFF (F-8-F-amide) neuropeptides. Both NPFF proteins may be activated by synthetic or naturally occurring FMRF-amide-like ligands. The receptors are mediated by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. NPFF1 Receptors is highly expressed in the human hypothalamus and amygdala, indicating a possible role for NPFF1 in central autonomic and neuroendocrine control in the human brain. Based in part on NPFF2 Receptor expression in diencephalon and superficial layers of the spinal cord, NPFF2 Receptor is thought to be involved in the modulation of sensory input and opioid analgesia. Function: Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Subcellular Location: Cell membrane. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 64106 Human Entrez Gene: 64107 Rat Omim: 607448 Human SwissProt: Q9GZQ6 Human SwissProt: Q9EP86 Rat Unigene: 302026 Human Unigene: 64483 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
神经肽FF 1受体（NPFF1或hFF1）和神经肽FF 2受体（NPFF2）属于G蛋白偶联受体1家族。NPFF1和NPFF2都是作为NPAF(A-18-F-酰胺)和NPFF(F-8-F-酰胺)神经肽受体的整体膜蛋白。NPFF蛋白可以由合成的或天然存在的FMRF酰胺类配体激活。受体是通过与激活磷酸磷脂酰肌醇钙第二信使系统的G蛋白关联而介导的。NPFF1受体在人下丘脑和杏仁核高度表达，表明NPFF1可能在人脑中枢自主神经和神经内分泌控制中发挥作用。根据NPFF2受体在脊髓中脑和脊髓浅层的部分表达，NPFF2受体被认为参与调节感觉输入和阿片镇痛。